ZFIN is now using GRCz12tu for Genomic Data
Gene
kcnma1b
- ID
- ZDB-GENE-101209-2
- Name
- potassium large conductance calcium-activated channel, subfamily M, alpha member 1b
- Symbol
- kcnma1b Nomenclature History
- Previous Names
-
- slo1b (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable large conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be active in postsynaptic membrane. Is expressed in several structures, including brain; neural rod; olfactory placode; otic vesicle; and presumptive diencephalon. Human ortholog(s) of this gene implicated in Alzheimer's disease; generalized epilepsy; and paroxysmal nonkinesigenic dyskinesia 3. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| paroxysmal nonkinesigenic dyskinesia 3 | Alliance | Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy | 609446 |
| Cerebellar atrophy, developmental delay, and seizures | 617643 | ||
| Liang-Wang syndrome | 618729 | ||
| {Epilepsy, idiopathic generalized, susceptibility to, 16} | 618596 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnma1-201
(1)
|
Ensembl | 1,389 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers
- Comparative Orthology
- Alliance