Gene
lig1
- ID
- ZDB-GENE-110404-2
- Name
- ligase I, DNA, ATP-dependent
- Symbol
- lig1 Nomenclature History
- Previous Names
-
- si:dkeyp-35b8.5
- si:dkeyp-35b8.7
- wu:fc54a11
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA ligase (ATP) activity. Predicted to be involved in DNA ligation and Okazaki fragment processing involved in mitotic DNA replication. Predicted to act upstream of or within DNA metabolic process. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Leontovich et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 96 | Alliance | Immunodeficiency 96 | 619774 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016059 | DNA ligase, ATP-dependent, conserved site |
| Domain | IPR012308 | DNA ligase, ATP-dependent, N-terminal |
| Domain | IPR012309 | DNA ligase, ATP-dependent, C-terminal |
| Domain | IPR012310 | DNA ligase, ATP-dependent, central |
| Family | IPR000977 | DNA ligase, ATP-dependent |
| Family | IPR050191 | ATP-dependent DNA ligase |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR036599 | DNA ligase, ATP-dependent, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent DNA ligase | DNA ligase, ATP-dependent | DNA ligase, ATP-dependent, central | DNA ligase, ATP-dependent, conserved site | DNA ligase, ATP-dependent, C-terminal | DNA ligase, ATP-dependent, N-terminal | DNA ligase, ATP-dependent, N-terminal domain superfamily | Nucleic acid-binding, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S533 | InterPro | 1058 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available