Gene
agtr1b
- ID
- ZDB-GENE-110411-117
- Name
- angiotensin II receptor, type 1b
- Symbol
- agtr1b Nomenclature History
- Previous Names
-
- si:dkey-65o9.2
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable angiotensin type I receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; inflammatory response; and positive regulation of cytosolic calcium ion concentration. Predicted to be active in plasma membrane. Is expressed in brain; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | {Hypertension, essential} | 145500 |
| Renal tubular dysgenesis | 267430 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Angiotensin II receptor family | Angiotensin II receptor type 1 | C-C chemokine receptor type 1-9-like | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7FEQ8 | InterPro | 359 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
agtr1b-201
(1)
|
Ensembl | 1,080 nt | ||
| mRNA |
agtr1b-202
(1)
|
Ensembl | 1,393 nt |
Interactions and Pathways
No data available
Plasmids
No data available