dnah5

ID

ZDB-GENE-110411-177

Name

dynein, axonemal, heavy chain 5

Symbol

dnah5 Nomenclature History

Previous Names

si:ch211-119d19.1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and outer dynein arm assembly. Predicted to act upstream of or within microtubule-based movement. Predicted to be located in axoneme and microtubule. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in Kupffer's vesicle; olfactory epithelium; and testis. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnah5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary ciliary dyskinesia 3	Alliance	Ciliary dyskinesia, primary, 3, with or without situs inversus	608644

Associated With dnah5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR013594	Dynein heavy chain, tail
Domain	IPR013602	Dynein heavy chain, linker
Domain	IPR024317	Dynein heavy chain, AAA module D4
Domain	IPR024743	Dynein heavy chain, coiled coil stalk
Domain	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
Domain	IPR035706	Dynein heavy chain, ATP-binding dynein motor region
Domain	IPR041228	Dynein heavy chain, C-terminal domain
Domain	IPR041466	Dynein heavy chain, AAA 5 extension domain
Domain	IPR041589	Dynein heavy chain 3, AAA+ lid domain
Domain	IPR056759	Dynein axonemal heavy chain 2/5/8, coiled-coil domain
Family	IPR026983	Dynein heavy chain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR042222	Dynein heavy chain, domain 2, N-terminal
Homologous_superfamily	IPR042228	Dynein heavy chain, linker, subdomain 3
Homologous_superfamily	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain
Homologous_superfamily	IPR043160	Dynein heavy chain, C-terminal domain, barrel region

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PMV7	InterPro	4638
UniProtKB:A0A8M9PDG5	InterPro	4639
UniProtKB:A0A8M9PJW7	InterPro	4129
UniProtKB:A0AC58HIN8	InterPro	4638
UniProtKB:A0AC58HIP3	InterPro	4602
UniProtKB:A0AC58HIQ1	InterPro	4637
UniProtKB:A0AC58HIQ3	InterPro	4646
UniProtKB:A0AC58HIQ6	InterPro	4648
UniProtKB:A0AC58HIT2	InterPro	4647
UniProtKB:A0AC58HIT8	InterPro	4603
UniProtKB:A0AC58HIV8	InterPro	4647