ZFIN is now using GRCz12tu for Genomic Data
Gene
inpp5b
- ID
- ZDB-GENE-110411-228
- Name
- inositol polyphosphate-5-phosphatase B
- Symbol
- inpp5b Nomenclature History
- Previous Names
-
- si:ch211-175f12.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable inositol-1,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Acts upstream of or within several processes, including Kupffer's vesicle development; melanosome transport; and pronephric duct morphogenesis. Predicted to be located in early endosome membrane and phagocytic vesicle membrane. Predicted to be active in cytosol; membrane; and neuron projection. Orthologous to human INPP5B (inositol polyphosphate-5-phosphatase B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Luo et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR000300 | Inositol polyphosphate-related phosphatase |
| Domain | IPR031896 | INPP5B, PH domain |
| Domain | IPR037793 | OCRL1/INPP5B, INPP5c domain |
| Domain | IPR047078 | Inositol polyphosphate 5-phosphatase OCRL, RhoGAP |
| Domain | IPR048869 | OCRL-1/2, ASH domain |
| Family | IPR046985 | Inositol 5-phosphatase |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036691 | Endonuclease/exonuclease/phosphatase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Endonuclease/exonuclease/phosphatase superfamily | Immunoglobulin-like fold | Inositol 5-phosphatase | Inositol polyphosphate 5-phosphatase OCRL, RhoGAP | Inositol polyphosphate-related phosphatase | INPP5B, PH domain | OCRL-1/2, ASH domain | OCRL1/INPP5B, INPP5c domain | Rho GTPase-activating protein domain | Rho GTPase activation protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YTK6 | InterPro | 744 | ||||||||||
| UniProtKB:A0A8M6YVC4 | InterPro | 573 | ||||||||||
| UniProtKB:A0A8M3AQB1 | InterPro | 907 | ||||||||||
| UniProtKB:A0A8M6Z189 | InterPro | 803 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
inpp5b-202
(1)
|
Ensembl | 871 nt | ||
| mRNA |
inpp5b-203
(1)
|
Ensembl | 3,427 nt | ||
| ncRNA |
inpp5b-002
(1)
|
Ensembl | 869 nt | ||
| ncRNA |
inpp5b-003
(1)
|
Ensembl | 350 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers