Gene
kif5ab
- ID
- ZDB-GENE-110510-3
- Name
- kinesin family member 5A, b
- Symbol
- kif5ab Nomenclature History
- Previous Names
-
- si:ch73-130n22.1
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and cytoskeletal motor activity. Predicted to be involved in system development. Predicted to be located in cytoplasm and microtubule. Is expressed in nervous system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 25; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Campbell et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 25 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to, 25} | 617921 |
| hereditary spastic paraplegia 10 | Alliance | Spastic paraplegia 10, autosomal dominant | 604187 |
| Myoclonus, intractable, neonatal | 617235 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PSD5 | InterPro | 1023 | |||||
| UniProtKB:A0A8M3ATT8 | InterPro | 1050 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kif5ab-201
(1)
|
Ensembl | 3,262 nt | ||
| mRNA |
kif5ab-202
(1)
|
Ensembl | 972 nt |
Interactions and Pathways
No data available
Plasmids
No data available