ZFIN is now using GRCz12tu for Genomic Data
Gene
parlb
- ID
- ZDB-GENE-110804-1
- Name
- presenilin associated, rhomboid-like b
- Symbol
- parlb Nomenclature History
- Previous Names
-
- parla (2)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing and regulation of mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in brain; heart; liver; and muscle. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Peptidase S54, rhomboid domain | Rhomboid-like superfamily | Rhomboid protease S54 |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PIW5 | InterPro | 361 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance