ZFIN is now using GRCz12tu for Genomic Data
Gene
irs4a
- ID
- ZDB-GENE-120215-92
- Name
- insulin receptor substrate 4a
- Symbol
- irs4a Nomenclature History
- Previous Names
-
- si:ch73-362m14.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 9 and lung cancer. Orthologous to human IRS4 (insulin receptor substrate 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zhang et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nongoitrous hypothyroidism 9 | Alliance | Hypothyroidism, congenital, nongoitrous, 9 | 301035 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|
| UniProtKB:E7FCJ4 | InterPro | 1051 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers