ZFIN is now using GRCz12tu for Genomic Data
Gene
kcnj2a
- ID
- ZDB-GENE-120319-1
- Name
- potassium inwardly rectifying channel subfamily J member 2a
- Symbol
- kcnj2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane. Predicted to be located in T-tubule. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including heart; myotome; olfactory system; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Andersen-Tawil syndrome | Alliance | Andersen syndrome | 170390 |
| familial atrial fibrillation | Alliance | Atrial fibrillation, familial, 9 | 613980 |
| short QT syndrome | Alliance | Short QT syndrome 3 | 609622 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013673 | Potassium channel, inwardly rectifying, Kir, N-terminal |
| Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
| Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
| Family | IPR003271 | Potassium channel, inwardly rectifying, Kir2.1 |
| Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
| Homologous_superfamily | IPR013518 | Potassium channel, inwardly rectifying, Kir, cytoplasmic |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir2.1 | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, Kir, N-terminal | Potassium channel, inwardly rectifying, transmembrane domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FGH1 | InterPro | 427 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnj2a-201
(1)
|
Ensembl | 1,515 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers