il6

ID

ZDB-GENE-120509-1

Name

interleukin 6 (interferon, beta 2)

Symbol

il6 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine activity; growth factor activity; and interleukin-6 receptor binding activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in extracellular space. Is expressed in several structures, including bone tissue; epidermis; heart; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

130 figures from 106 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
arteriovenous malformations of the brain	Alliance	{Intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to}	108010
inflammatory bowel disease 1	Alliance	{Crohn disease-associated growth failure}	266600
juvenile rheumatoid arthritis	Alliance	{Rheumatoid arthritis, systemic juvenile}	604302
type 1 diabetes mellitus	Alliance	{Type 1 diabetes mellitus}	222100
type 2 diabetes mellitus	Alliance	{Type 2 diabetes mellitus}	125853
		{Kaposi sarcoma in HIV+, susceptibility to}	148000