ZFIN is now using GRCz12tu for Genomic Data
Gene

tpp2

ID
ZDB-GENE-121214-290
Name
tripeptidyl peptidase 2
Symbol
tpp2 Nomenclature History
Previous Names
  • si:ch73-244f7.4
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable tripeptidyl-peptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in cytosol. Is expressed in embryonic structure. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Yang et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tpp2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency 78 with autoimmunity and developmental delay 619220
Associated With tpp2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR022398 Peptidase S8, subtilisin, His-active site
Active_site IPR023828 Peptidase S8, subtilisin, Ser-active site
Domain IPR000209 Peptidase S8/S53 domain
Domain IPR022229 Tripeptidyl peptidase II, second Ig-like domain
Domain IPR022232 Tripeptidyl peptidase II, C-terminal domain, arthropoda
Domain IPR034051 Tripeptidyl-peptidase II domain
Domain IPR048383 Tripeptidyl-peptidase II, first Ig-like domain
Domain IPR048384 Tripeptidyl-peptidase II, galactose-binding domain-like
Family IPR015500 Peptidase S8, subtilisin-related
Family IPR050131 Subtilisin-like serine protease
Homologous_superfamily IPR036852 Peptidase S8/S53 domain superfamily
Homologous_superfamily IPR046939 Tripeptidyl-peptidase 2, C-terminal domain superfamily
Homologous_superfamily IPR046940 Tripeptidyl peptidase II, Ig-like domain superfamily
Domain Details Per Protein
Protein Additional Resources Length Peptidase S8/S53 domain Peptidase S8/S53 domain superfamily Peptidase S8, subtilisin, His-active site Peptidase S8, subtilisin-related Peptidase S8, subtilisin, Ser-active site Subtilisin-like serine protease Tripeptidyl-peptidase 2, C-terminal domain superfamily Tripeptidyl peptidase II, C-terminal domain, arthropoda Tripeptidyl-peptidase II domain Tripeptidyl-peptidase II, first Ig-like domain Tripeptidyl-peptidase II, galactose-binding domain-like Tripeptidyl peptidase II, Ig-like domain superfamily Tripeptidyl peptidase II, second Ig-like domain
UniProtKB:A0A8M2BG24 InterPro 1262
UniProtKB:R4GDQ0 InterPro 1263
UniProtKB:A0A8M1RJV2 InterPro 1249
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tpp2-201 (1)
Ensembl
Ensembl 5,496 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Citations
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