ZFIN is now using GRCz12tu for Genomic Data
Gene
epob
- ID
- ZDB-GENE-141216-428
- Name
- erythropoietin b
- Symbol
- epob Nomenclature History
- Previous Names
-
- si:dkey-259i8.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable erythropoietin receptor binding activity; protein kinase activator activity; and receptor ligand activity. Predicted to be involved in cell surface receptor signaling pathway via STAT; erythrocyte differentiation; and erythropoietin-mediated signaling pathway. Predicted to be active in extracellular region. Is expressed in dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from She et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from She et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial erythrocytosis 5 | Alliance | Erythrocytosis, familial, 5 | 617907 |
| ?Diamond-Blackfan anemia-like | 617911 | ||
| {Microvascular complications of diabetes 2} | 612623 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Erythropoietin | Erythropoietin/thrombopoietin | Four-helical cytokine-like, core |
|---|---|---|---|---|---|
| UniProtKB:A0A8M3AWM3 | InterPro | 181 | |||
| UniProtKB:A0A8M9QCG3 | InterPro | 182 | |||
| UniProtKB:A0A8M9QL13 | InterPro | 181 | |||
| UniProtKB:A0AC58GII3 | InterPro | 127 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers