clcn2b

ID

ZDB-GENE-151006-1

Name

chloride channel, voltage-sensitive 2b

Symbol

clcn2b Nomenclature History

Previous Names

clc-2b (1)

Type

protein_coding_gene

Location

Ambiguous Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables chloride channel activity. Predicted to be involved in chloride transport. Located in cell junction. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With clcn2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary hyperaldosteronism	Alliance	Hyperaldosteronism, familial, type II	605635
		Leukoencephalopathy with ataxia	615651
		{Epilepsy, idiopathic generalized, susceptibility to, 11}	607628
		{Epilepsy, juvenile absence, susceptibility to, 2}	607628
		{Epilepsy, juvenile myoclonic, susceptibility to, 8}	607628

Associated With clcn2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001807	Chloride channel
Family	IPR002244	Chloride channel ClC-2
Family	IPR050970	Voltage-gated chloride channel
Homologous_superfamily	IPR014743	Chloride channel, core
Homologous_superfamily	IPR046342	CBS domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A0G2KI62	InterPro
UniProtKB:A0A098DN12	InterPro	898
UniProtKB:A0A8M3AV80	InterPro	894
UniProtKB:A0A8M3AV81	InterPro	911
UniProtKB:A0AB32TF16	InterPro	881