ZFIN is now using GRCz12tu for Genomic Data

Gene

pou3f2a

ID

ZDB-GENE-980526-139

Name

POU class 3 homeobox 2a

Symbol

pou3f2a Nomenclature History

Previous Names

brn1.2
id:ibd5088

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in brain; neural keel; neural plate; and spinal cord. Orthologous to human POU3F2 (POU class 3 homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Kasher et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pou3f2a Human Ortholog

No data available

Associated With pou3f2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR000327	POU-specific domain
Domain	IPR001356	Homeodomain
Domain	IPR013847	POU domain
Family	IPR016362	POU-domain transcription factor, class 3
Family	IPR050255	POU domain transcription factor
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Homedomain-like superfamily	Homeobox, conserved site	Homeodomain	Lambda repressor-like, DNA-binding domain superfamily	POU domain	POU domain transcription factor	POU-domain transcription factor, class 3	POU-specific domain
UniProtKB:A2VD21	InterPro	337

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pou3f2a-201 (1) Ensembl	Ensembl		2,725 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Gates, et al. (1999. Genome Res. 9:334-347.) reported orthology to human POU3F1 and mouse Pou3f1. Subsequent analysis suggests this gene is the ortholog of human POU3F2 and mouse Pou3f2 based on amino acid identity and conserved location.

Citations