Gene
apoeb
- ID
- ZDB-GENE-980526-368
- Name
- apolipoprotein Eb
- Symbol
- apoeb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including cholesterol efflux; phospholipid efflux; and triglyceride-rich lipoprotein particle clearance. Predicted to be located in extracellular matrix and extracellular space. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in several structures, including epidermis; fin bud; hematopoietic cell; median fin; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 92 figures from 57 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb82 (8 images)
- eu173 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Hu et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 1 | Alliance | {?Macular degeneration, age-related} | 603075 |
| Alzheimer's disease 2 | Alliance | Alzheimer disease 2 | 104310 |
| Alzheimer's disease 3 | Alliance | {?Alzheimer disease, protection against, due to APOE3-Christchurch} | 607822 |
| hyperlipoproteinemia type III | Alliance | Hyperlipoproteinemia, type III | 617347 |
| hyperlipoproteinemia type III | Alliance | {Coronary artery disease, severe, susceptibility to} | 617347 |
| sea-blue histiocytosis | Alliance | Sea-blue histiocyte disease | 269600 |
| Lipoprotein glomerulopathy | 611771 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|---|
| UniProtKB:O42364 | InterPro | 281 |
Interactions and Pathways
No data available
Plasmids