ZFIN is now using GRCz12tu for Genomic Data
Gene
gdf3
- ID
- ZDB-GENE-980526-389
- Name
- growth differentiation factor 3
- Symbol
- gdf3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine activity. Involved in regulation of epiboly involved in gastrulation with mouth forming second. Acts upstream of or within axis specification; embryonic morphogenesis; and neuron development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastomere; gonad; heart primordium; mesoderm; and tail bud. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 3; congenital heart disease; isolated microphthalmia 7; multiple types of congenital heart defects 6; and right atrial isomerism. Orthologous to several human genes including GDF3 (growth differentiation factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb556 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 7 | Alliance | Microphthalmia, isolated 7 | 613704 |
| Klippel-Feil syndrome 3 | Alliance | Klippel-Feil syndrome 3, autosomal dominant | 613702 |
| Microphthalmia, isolated, with coloboma 6 | 613703 |
Domain, Family, and Site Summary
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers