tal1

ID

ZDB-GENE-980526-501

Name

T-cell acute lymphocytic leukemia 1

Symbol

tal1 Nomenclature History

Previous Names

tal-1
scl/tal1
scl
zgc:85605 (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables sequence-specific DNA binding activity. Involved in circulatory system development and hemopoiesis. Acts upstream of or within several processes, including circulatory system development; hemopoiesis; and positive regulation of endothelial cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; hematopoietic cell; hematopoietic system; and mesoderm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

363 figures from 234 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85605 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 26 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tal1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute lymphoblastic leukemia	Alliance	Leukemia, T-cell acute lymphocytic, somatic	613065

Associated With tal1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Family	IPR040238	Helix-loop-helix protein TAL-like
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily