ZFIN is now using GRCz12tu for Genomic Data
Gene
ptpn1
- ID
- ZDB-GENE-980605-23
- Name
- protein tyrosine phosphatase non-receptor type 1
- Symbol
- ptpn1 Nomenclature History
- Previous Names
-
- PTP-1B (1)
- ptp1b
- fk54h03
- wu:fk54h03
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and protein kinase binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of PERK-mediated unfolded protein response. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in early endosome and endoplasmic reticulum. Is expressed in liver. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66113 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Insulin resistance, susceptibility to} | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Family | IPR012265 | Protein-tyrosine phosphatase, non-receptor type-1/2 |
| Family | IPR051985 | Non-receptor type tyrosine-specific phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | Non-receptor type tyrosine-specific phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-1/2 | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZWI6 | InterPro | 461 | |||||||
| UniProtKB:Q9PT91 | InterPro | 433 | |||||||
| UniProtKB:A0A8M1P706 | InterPro | 433 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers