atoh1a

ID

ZDB-GENE-990415-17

Name

atonal bHLH transcription factor 1a

Symbol

atoh1a Nomenclature History

Previous Names

ath1
Atoh1.1 (1)
atoh1
ZATH-1 (1)
zath1 (1)
Zath1a (1)
zgc:136417

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables chromatin binding activity. Acts upstream of or within mechanoreceptor differentiation. Predicted to be active in nucleus. Is expressed in hindbrain neural keel; nervous system; neural tube; otic epithelium; and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 89. Orthologous to human ATOH1 (atonal bHLH transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

115 figures from 75 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atoh1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 89	Alliance	?Deafness, autosomal dominant 89	620284

Associated With atoh1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR032661	Transcription factor ATOH1, basic helix-loop-helix domain
Family	IPR050359	Basic helix-loop-helix transcription factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily