ZFIN is now using GRCz12tu for Genomic Data
Gene
fzd4
- ID
- ZDB-GENE-990415-217
- Name
- frizzled class receptor 4
- Symbol
- fzd4 Nomenclature History
- Previous Names
-
- fz1
- zg01
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within retina homeostasis and retina vasculature development in camera-type eye. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; neural plate; and neurogenic placode. Used to study exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4).
- Genome Resources
-
- Alliance (1)
- Gene:30363 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Caceres et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| exudative vitreoretinopathy 1 | Alliance | Exudative vitreoretinopathy 1 | 133780 |
| exudative vitreoretinopathy 1 | Alliance | Retinopathy of prematurity | 133780 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| exudative vitreoretinopathy | fzd4zf3345/zf3345; y1Tg (AB) | standard conditions | Caceres et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000539 | Frizzled/Smoothened, 7TM |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Domain | IPR020067 | Frizzled domain |
| Domain | IPR026551 | Frizzled-4, 7TM |
| Domain | IPR041765 | Frizzled 4, cysteine-rich domain |
| Family | IPR015526 | Frizzled/secreted frizzled-related protein |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled-4, 7TM | Frizzled 4, cysteine-rich domain | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, 7TM | GPCR, family 2-like, 7TM |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IVK2 | InterPro | 523 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance