ZFIN is now using GRCz12tu for Genomic Data
Gene
pou4f3
- ID
- ZDB-GENE-990415-24
- Name
- POU class 4 homeobox 3
- Symbol
- pou4f3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in auditory receptor cell; neuromast hair cell; and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15. Orthologous to human POU4F3 (POU class 4 homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 15 | Alliance | Deafness, autosomal dominant 15/52 | 602459 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR000327 | POU-specific domain |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR013847 | POU domain |
| Family | IPR050255 | POU domain transcription factor |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
| Homologous_superfamily | IPR010982 | Lambda repressor-like, DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily | POU domain | POU domain transcription factor | POU-specific domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90435 | InterPro | 331 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pou4f3-201
(1)
|
Ensembl | 996 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers