ZFIN is now using GRCz12tu for Genomic Data
Gene
thraa
- ID
- ZDB-GENE-990415-263
- Name
- thyroid hormone receptor alpha a
- Symbol
- thraa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables nuclear receptor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including positive regulation of sarcomere organization; thyroid hormone receptor signaling pathway; and ventricular system development. Located in nucleus. Is expressed in several structures, including blastodisc; muscle; nervous system; optic cup; and pleuroperitoneal region. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (thyroid hormone receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109800 (1 image)
- u54796 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nongoitrous hypothyroidism 6 | Alliance | Hypothyroidism, congenital, nongoitrous, 6 | 614450 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hypothyroidism | AB + MO4-thraa | standard conditions | Marelli et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR001728 | Thyroid hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q98867 | InterPro | 427 | |||||||
| UniProtKB:A0A8M3B8B2 | InterPro | 407 | |||||||
| UniProtKB:B2GQG7 | InterPro | 427 | |||||||
| UniProtKB:A0A8M2BB68 | InterPro | 421 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers