ZFIN is now using GRCz12tu for Genomic Data
Gene
thrb
- ID
- ZDB-GENE-990415-268
- Name
- thyroid hormone receptor beta
- Symbol
- thrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables nuclear receptor activity. Acts upstream of or within several processes, including inner ear development; retinal cone cell differentiation; and thyroid hormone receptor signaling pathway. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; gonad; liver; and optic vesicle. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- af109732 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| selective pituitary thyroid hormone resistance | Alliance | Thyroid hormone resistance, selective pituitary | 145650 |
| thyroid hormone resistance syndrome | Alliance | Thyroid hormone resistance | 188570 |
| thyroid hormone resistance syndrome | Alliance | Thyroid hormone resistance, autosomal recessive | 274300 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| thyroid hormone resistance syndrome | AB + MO4-thrb | standard conditions | Marelli et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR001728 | Thyroid hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B694 | InterPro | 479 | |||||||
| UniProtKB:S6BPQ3 | InterPro | 488 | |||||||
| UniProtKB:Q9PVE4 | InterPro | 395 | |||||||
| UniProtKB:A0A8M2B654 | InterPro | 268 | |||||||
| UniProtKB:A0A2R8QK91 | InterPro | 508 | |||||||
| UniProtKB:A0A8M9PN36 | InterPro | 281 | |||||||
| UniProtKB:A0A8M9PRA9 | InterPro | 415 | |||||||
| UniProtKB:A0A8M3AK49 | InterPro | 240 | |||||||
| UniProtKB:A0AB32T7V3 | InterPro | 398 | |||||||
| UniProtKB:A0AB32TCT8 | InterPro | 386 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
thrb-201
(1)
|
Ensembl | 1,992 nt | ||
| mRNA |
thrb-203
(1)
|
Ensembl | 3,136 nt | ||
| mRNA |
thrb-204
(1)
|
Ensembl | 5,600 nt | ||
| mRNA |
thrb-205
(1)
|
Ensembl | 2,198 nt | ||
| mRNA |
thrb-206
(1)
|
Ensembl | 5,732 nt | ||
| mRNA |
thrb-207
(1)
|
Ensembl | 5,822 nt | ||
| mRNA |
thrb-208
(1)
|
Ensembl | 5,804 nt | ||
| mRNA |
thrb-209
(1)
|
Ensembl | 5,795 nt | ||
| mRNA |
thrb-210
(1)
|
Ensembl | 5,629 nt | ||
| ncRNA |
thrb-002
(1)
|
Ensembl | 1,234 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers