ZFIN is now using GRCz12tu for Genomic Data
Gene
dlx4b
- ID
- ZDB-GENE-990415-50
- Name
- distal-less homeobox 4b
- Symbol
- dlx4b Nomenclature History
- Previous Names
-
- dlx7
- fj03c01
- wu:fj03c01
- zgc:109858
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; inner ear development; and lens fiber cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; ectoderm; inner dental epithelium; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in orofacial cleft 15. Orthologous to human DLX4 (distal-less homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109858 (12 images)
- eu510 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wu et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| orofacial cleft 15 | Alliance | ?Orofacial cleft 15 | 616788 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000047 | Helix-turn-helix motif |
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR020479 | Homeodomain, metazoa |
| Family | IPR050460 | Distal-less homeobox transcription factors |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Distal-less homeobox transcription factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q98878 | InterPro | 254 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers