foxa1

ID

ZDB-GENE-990415-78

Name

forkhead box A1

Symbol

foxa1 Nomenclature History

Previous Names

fkd7 (1)
forkhead-7

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables transcription cis-regulatory region binding activity. Acts upstream of or within axial mesoderm morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; chordo neural hinge; digestive system; endoderm; and liver primordium. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human FOXA1 (forkhead box A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

65 figures from 56 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:65744 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Lai et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxa1 Human Ortholog

No data available

Associated With foxa1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018122	Fork head domain conserved site1
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR013638	Fork-head N-terminal
Domain	IPR018533	Forkhead box protein, C-terminal
Family	IPR050211	Forkhead box domain-containing protein
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily