ZFIN is now using GRCz12tu for Genomic Data
Gene
hspa8
- ID
- ZDB-GENE-990415-92
- Name
- heat shock protein 8
- Symbol
- hspa8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable several functions, including ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within several processes, including fin regeneration; positive regulation of receptor-mediated endocytosis; and protein localization to early endosome. Predicted to be located in lysosome; membrane; and nucleolus. Predicted to be active in several cellular components, including cytosol; lysosomal membrane; and nucleus. Is expressed in several structures, including central nervous system; head; immature eye; presumptive neural plate; and swim bladder. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55272 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
| Family | IPR013126 | Heat shock protein 70 family |
| Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
| Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
| Homologous_superfamily | IPR043129 | ATPase, nucleotide binding domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATPase, nucleotide binding domain | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90473 | InterPro | 649 | |||||
| UniProtKB:Q6NYR4 | InterPro | 649 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers