ZFIN is now using GRCz12tu for Genomic Data

Gene

svila

ID

ZDB-GENE-990706-5

Name

supervillin a

Symbol

svila Nomenclature History

Previous Names

svil
sb:cb867
wu:fd05a09
zmp:0000000648 (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytoskeleton and membrane. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; optic vesicle; and sensory system. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb867 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Deo et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With svila Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myofibrillar myopathy 10	Alliance	Myofibrillar myopathy 10	619040

Associated With svila Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003128	Villin headpiece
Domain	IPR007123	Gelsolin-like domain
Family	IPR007122	Villin/Gelsolin
Homologous_superfamily	IPR029006	ADF-H/Gelsolin-like domain superfamily
Homologous_superfamily	IPR036886	Villin headpiece domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9Q864	InterPro	2239
UniProtKB:A0A8M9QII8	InterPro	2264
UniProtKB:A0A8M9QE30	InterPro	2208
UniProtKB:A0A8M9PW23	InterPro	2241
UniProtKB:A0A8M9QIJ4	InterPro	1847
UniProtKB:A0A8M9QMC6	InterPro	1919
UniProtKB:Q38HW9	InterPro	1763
UniProtKB:F1Q6K8	InterPro	1763
UniProtKB:A0AB13ABN4	InterPro	2264
UniProtKB:A0AB32TYD5	InterPro	1840
UniProtKB:A0AC58GUK0	InterPro	2115
UniProtKB:A0AC58GUK1	InterPro	2132
UniProtKB:A0AC58GUK3	InterPro	2127
UniProtKB:A0AC58GUK4	InterPro	2120
UniProtKB:A0AC58GUK5	InterPro	2111
UniProtKB:A0AC58GUK6	InterPro	2128
UniProtKB:A0AC58GUK7	InterPro	2160
UniProtKB:A0AC58GUL0	InterPro	2104
UniProtKB:A0AC58GUL3	InterPro	2110
UniProtKB:A0AC58GUL4	InterPro	2216
UniProtKB:A0AC58GUL5	InterPro	1880
UniProtKB:A0AC58GUL6	InterPro	2131
UniProtKB:A0AC58GUL7	InterPro	2100
UniProtKB:A0AC58GUL8	InterPro	2094
UniProtKB:A0AC58GUL9	InterPro	2044
UniProtKB:A0AC58GUM1	InterPro	2075
UniProtKB:A0AC58GUM2	InterPro	2083
UniProtKB:A0AC58GUM3	InterPro	2036
UniProtKB:A0AC58GUM4	InterPro	1896
UniProtKB:A0AC58GUM5	InterPro	1873
UniProtKB:A0AC58GUM6	InterPro	2087
UniProtKB:A0AC58GUM7	InterPro	1879
UniProtKB:A0AC58GUM8	InterPro	2088
UniProtKB:A0AC58GUM9	InterPro	1878
UniProtKB:A0AC58GUN0	InterPro	1824
UniProtKB:A0AC58GUN1	InterPro	1839
UniProtKB:A0AC58GUN2	InterPro	2095
UniProtKB:A0AC58GUN3	InterPro	1862
UniProtKB:A0AC58GUN6	InterPro	1846
UniProtKB:A0AC58GUN7	InterPro	2076
UniProtKB:A0AC58GUN9	InterPro	1830
UniProtKB:A0AC58GUP0	InterPro	1847
UniProtKB:A0AC58GUP1	InterPro	1864
UniProtKB:A0AC58GUP2	InterPro	1848
UniProtKB:A0AC58GUP3	InterPro	1831
UniProtKB:A0AC58GUP8	InterPro	1863
UniProtKB:A0AC58GUP9	InterPro	1856

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	svila-207 (1) Ensembl	Ensembl	750 nt	Select Tool ZFIN BLAST
mRNA	svila-201 (1) Ensembl	Ensembl	6,407 nt	Select Tool ZFIN BLAST
mRNA	svila-202 (1) Ensembl	Ensembl	511 nt	Select Tool ZFIN BLAST
mRNA	svila-203 (1) Ensembl	Ensembl	2,851 nt	Select Tool ZFIN BLAST
mRNA	svila-204 (1) Ensembl	Ensembl	553 nt	Select Tool ZFIN BLAST
mRNA	svila-205 (1) Ensembl	Ensembl	896 nt	Select Tool ZFIN BLAST
mRNA	svila-208 (1) Ensembl	Ensembl	8,812 nt	Select Tool ZFIN BLAST
mRNA	svila-209 (1) Ensembl	Ensembl	8,791 nt	Select Tool ZFIN BLAST
ncRNA	svila-005 (1) Ensembl	Ensembl	378 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance

Citations