ZFIN is now using GRCz12tu for Genomic Data
Gene
ucp2
- ID
- ZDB-GENE-990708-8
- Name
- uncoupling protein 2
- Symbol
- ucp2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including blood; brain; cardiovascular system; pleuroperitoneal region; and ventral mesoderm. Human ortholog(s) of this gene implicated in cerebrovascular disease (multiple); diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb74 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Obesity, susceptibility to, BMIQ4} | 607447 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitochondrial carrier protein | Mitochondrial Metabolite Transporter |
|---|---|---|---|---|
| UniProtKB:Q6P0I3 | InterPro | 310 | ||
| UniProtKB:A0A8M3B6H4 | InterPro | 258 | ||
| UniProtKB:Q9W720 | InterPro | 310 | ||
| UniProtKB:A0AC58GK79 | InterPro | 310 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers