ZFIN is now using GRCz12tu for Genomic Data
Gene
tbx5a
- ID
- ZDB-GENE-991124-7
- Name
- T-box transcription factor 5a
- Symbol
- tbx5a Nomenclature History
- Previous Names
-
- tbx5.1
- tbx5
- zf-tbx5
- zTbx5
- etID310031.5 (1)
- heartstrings
- hst
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables DNA-binding transcription factor activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; heart development; and limb development. Located in actin cytoskeleton and nucleus. Is expressed in several structures, including eye; immature eye; mesoderm; pectoral fin; and pericardial region. Used to study Holt-Oram syndrome. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Orthologous to human TBX5 (T-box transcription factor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 161 figures from 102 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu790 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 58 figures from 26 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Holt-Oram syndrome | Alliance | Holt-Oram syndrome | 142900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QDI3 | InterPro | 492 | |||||
| UniProtKB:Q9IAK8 | InterPro | 492 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers