ZFIN is now using GRCz12tu for Genomic Data
Gene
sema3aa
- ID
- ZDB-GENE-991209-3
- Name
- sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa
- Symbol
- sema3aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Acts upstream of or within blood vessel morphogenesis and nervous system development. Predicted to be active in several cellular components, including axon; extracellular region; and glutamatergic synapse. Is expressed in several structures, including anterior neural rod; brain; head; immature eye; and muscle. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to human SEMA3A (semaphorin 3A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 16 with or without anosmia | Alliance | {Hypogonadotropic hypogonadism 16 with or without anosmia} | 614897 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001627 | Sema domain |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR016201 | PSI domain |
| Family | IPR027231 | Semaphorin |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W7J1 | InterPro | 860 | |||||||||
| UniProtKB:A0AC58J579 | InterPro | 822 | |||||||||
| UniProtKB:A0AC58J591 | InterPro | 822 | |||||||||
| UniProtKB:A0AC58J595 | InterPro | 822 | |||||||||
| UniProtKB:A0AC58J597 | InterPro | 822 | |||||||||
| UniProtKB:A0AC58J5A0 | InterPro | 822 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema3aa-201
(1)
|
Ensembl | 4,617 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers