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Fig. S3
heart development after PD0325901 treatments. Lateral views of 4 dpf embryos treated with increasing concentrations of PD0325901. Addition of the inhibitor, even at low concentrations (0.1 μM) blocked the cardiac valve and blood remained restricted in the heart chambers. Cardiac oedemas were frequently observed. Blood circulation of embryos treated at 3 dpf was not affected at 4 dpf, but continual follow-up showed that these embryos eventually developed heart oedemas with variable time of onset. The numbers of embryos displaying the heart phenotype are indicated.
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Full text @ Dis. Model. Mech.