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Fig. 6
Model for Hand2 influences on positional memory. Adult zebrafish pectoral fins maintain region-specific expression of transcription factor genes. Levels of the posterior transcription factor gene hand2 can help control bone patterning during pectoral fin regeneration. Hand2 levels regulate bone formation during regeneration by direct or indirect regulation of the vitamin D-inactivating enzyme encoded by cyp24a1, restricting bone formation in the posterior rays of pectoral fins.
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