Fig. 2
- ID
- ZDB-IMAGE-160505-13
- Publication
- Tan et al., 2016 - Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma
- All Figures
- Figures for Tan et al., 2016
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Fig. 2
HEXIM1 Activity Suppresses Melanoma In Vivo
(A) 19-week-old Tg(mitfa:BRAFV600E);p53-/-;mitfa-/- zebrafish are shown with rescued melanocytes expressing tumor accelerator SETDB1, background control EGFP, or HEXIM1/hexim1 in the MiniCoopR system.
(B) Tumor-free survival curves for EGFP, SETDB1, and HEXIM1/hexim1 MiniCoopR zebrafish over 25 weeks. Percentages of the total number of zebrafish that were tumor free each week are plotted.
(C) Tumor-free survival curves for MiniCoopR overexpression of human HEXIM1-4A, and HEXIM1-4D are shown.
(D) Tumor-free survival curves for MiniCoopR expression of p53 and hexim CRISPRs are shown.
(E) Tumor growth rates of individual mouse xenografts with a Tet-On HEXIM1-inducible A375 cell line (A375-HEXIM1) over 14 days. Mice were fed either a standard diet or doxycycline diet (mean of seven replicates ± SD).
See also Figure S2.