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Fig. S3
Live images showing morphology of 72 hpf embryos after fgf3 impairment with characteristic ear and craniofacial malformations. (A,B) Uninjected control (UC) and fgf3 morpholino injected (MO) siblings. (C,D) Cas9 injected control (C9C) and fgf3 CRISPR/Cas9 injected (CR) siblings. (E,F) Wildtype (+/+) and homozygous fgf3t24152 mutant (-/-) siblings. Boxes indicate magnified area shown in A’-F’. After fgf3 impairment the two otoliths fuse (arrow) and the lower jaw bones are malformed (arrow heads). Lateral views, anterior to the left. Scale bar in E, 100 μm; in E’, 50 μm.
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