Figure 1

Figure 1

Lactate and 3,5-dihydroxybenzoic acid (3,5-DHBA) promoted glioblastoma cell proliferation and migration. (A–C) Real-time cell proliferation monitoring in U-87 MG cells (A), A-172 cells (B), and U-251 cells (C) using the xCELLigence system following treatments with lactate (20 mM) and 3,5-DHBA (150 μM). The cell index values were normalized at the time of pharmacological treatments in order to obtain a normalized cell index. Each line expresses the average of four different experiments. (E–G) Analysis of human glioblastoma cell migration in U-87 MG cells (E), A-172 cells (D–F), and U-251 MG cells (G) with the wound healing assay following treatments with lactate (20 mM) and 3,5-DHBA (150 μM). The figures presented are representative of at least three independent experiments (mean ± SEM). P-values <0.05 were considered as statistically significant (*p < 0.05; ***p < 0.001).