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Figure Caption
Fig. 10 A model for the GPRC6A-mediated signaling causing a cardiac phenotype. (A) Testosterone activation of GPRC6A leads to activation of second messenger pathways that cause cardiac defects. The GPCR kinase GRK3 can reduce GPRC6A activity by promoting recruitment of β-arrestins. (B) Testosterone-mediated activation of GPRC6A inhibits or downregulates PAK1. (C) In the absence of testosterone, GPRC6A is less active. Created in BioRender. Gorelick, D. (2024) https://BioRender.com/y70f832.
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