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Fig. 2 Degarelix reduces Mtb survival in C57BL/6 mice. (a-d) Mice were aerosol-infected with 200 CFU H37Rv/mouse. Degarelix was administered just after infection via weekly intraperitoneal injection for up to 4 weeks. Lung histopathology was examined using bacterial CFUs (mean ± SEM of three mice infected for 4 weeks) (a), acid-fast (b; scale bars = 100 ?m and 20 ?m for upper and lower images, respectively; Arrows indicated the acid-fast staining positive H37Rv bacteria in lung tissue) and H&E staining (c, 1?3 = representative lung sections) in mouse lungs infected for 4 weeks. Histological scores (d).