ZFIN Image: Cero et al., 2024, Fig. 3

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Figure Caption

Fig. 3 Pathway and gene set enrichment analyses identify gene expression changes that uniquely characterize the cancer versus precancerous microenvironment.

A Canonical pathways identified by Ingenuity Pathways Analysis (IPA) that were predicted to be activated exclusively in the comparison of cancer versus precancerous microenvironments (MEs). B Genetic upstream regulators associated with predicted pathway activation as identified by IPA that were significantly upregulated exclusively in the comparison of cancer versus precancerous MEs. C Gene set enrichment analysis (GSEA) identifies six hallmark gene sets with a positive normalized enrichment score (NES) exclusively in the comparison of cancer versus precancerous MEs. D GSEA identifies 6 hallmark gene sets with a negative NES in the comparison of precancerous versus control MEs, but a positive NES in the comparison of cancer versus control MEs.

Acknowledgments

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