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Fig. 4 Effects of a high-fat diet (HFD) on metabolic parameters in adult Dhps-Δβ and Eif5a-Δβ mice. Eight-week-old male Eif5a-Δβ, Dhps-Δβ, and their respective littermate control mice received intraperitoneal tamoxifen injections over 1 week, allowed a week for recovery, and then placed on HFD (60% kcal from fat). N = 4 to 5 mice per group, and each point represents an individual mouse. A, diagram showing the experimental design of mouse studies. B, body weight, fat mass, and lean mass of Dhps-Δβ mice and control mice after 1 week of HFD. C, IPGTT and AUC of Dhps-Δβ mice and control mice after 1 week of HFD. D, body weight, fat mass, and lean mass of Eif5a-Δβ mice and control mice after 1 week of HFD. E, IPGTT and AUC representation of Eif5a-Δβ mice and control mice after 1 week of HFD. F, body weight, fat mass, and lean mass of Dhps-Δβ mice and control mice after 4 weeks of HFD. G, IPGTT and AUC of Dhps-Δβ mice and control mice after 4 weeks of HFD. H, body weight, fat mass, and lean mass of Eif5a-Δβ mice and Eif5a control mice after 4 weeks of HFD. I, IPGTT and AUC of Eif5a-Δβ mice and control mice after 4 weeks of HFD. Data are presented as mean ± SEM, and statistical significance was determined by an unpaired t test. AUC, area under the curve; IPGTT, intraperitoneal glucose tolerance test.