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Fig. 5 The defective BBB in cd248acc11/cc11 zebrafish can be rescued by cd248a mRNA.a Cerebrovascular images showing infiltration of cadaverine in the extravascular space, as indicated by red circle. Scale bar = 50 μm. b Quantification of pdgfrβ+ brain pericytes in cd248a+/+ and cd248acc11/cc11 larvae with or without mRNA injection (n = 8 larvae). c Quantitative analysis of fluorescence intensity within the red circle area (n = 8 larvae). Data were analyzed by One-way ANOVA and presented as mean ± SD. *, p < 0.05. **, p < 0.01. ****, p < 0.0001. ns: no significance.
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