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Fig. 4

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Publication: Yamashita et al., 2025 - Biallelic variants in DNAJC7 cause familial amyotrophic lateral sclerosis with the TDP-43 pathology
All Figures: Figures for Yamashita et al., 2025

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Fig. 4

RNA-seq analysis revealed that DNAJC7 expression was decreased in the motor cortex of the FALS cases with the DNAJC7 variant. a Bar graph showing the number of genes that were upregulated or downregulated in patients with FALS (IV-1, IV-4) compared to normal controls. b Waterfall plot depicting the top ten upregulated and downregulated genes in patients with FALS. c Volcano plot illustrating the statistical significance against the fold change for gene expression in patients with FALS. FALS, familial amyotrophic lateral sclerosis; RNA-seq, RNA sequencing

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