Figure 2

Figure 2

Ocular geometry measurements of 8-month-old and 1-year-old zebrafish

(A) shows an OCT 3-D volume in different cuts.

(B and C) display B-mode and en-face images with the measured parameters (scale bars, 500 μm).

(D–K) present estimation plots for normalized axial length (axial length/body length), RRE, Lens diameter, and proportion of lens diameter to normalized axial length for each group, respectively. (N = 30/genome/age). As it is shown, in the 8-month-old and 1-year-old group, the normalized axial length of the eye is significantly elongated, and RRE has a significant negative shift (p-value<0.001).

(L–O) shows the development of normalized axial length, RRE, lens diameter, and proportion of lens diameter to normalized axial length in Panx1a^+/+ versus Panx1a^−/− group in both developmental stages. Statistical analysis: Welch’s t test; Significance ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.