| 
            Phenotype
         | 
            
                Fish
             | 
            
                Conditions
             | 
        
            Figures
         | 
    
    
    
        
            | 
                angiogenesis process quality, abnormal
             | 
                
                    s843Tg + MO1-e2f7
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                dorsal longitudinal anastomotic vessel hypoplastic, abnormal
             | 
                
                    s843Tg + MO1-e2f7
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                intersegmental artery branching involved in blood vessel morphogenesis decreased process quality, abnormal
             | 
                
                    s843Tg + MO1-e2f7
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                intersegmental artery malformed, abnormal
             | 
                
                    s843Tg + MO1-e2f7
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                whole organism e2f1 expression increased amount, abnormal
             | 
                
                    WT + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                head nrp1a expression increased amount, abnormal
             | 
                
                    WT + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                whole organism nrp1b expression decreased amount, abnormal
             | 
                
                    WT + MO1-e2f7 + MO1-e2f8
                 | 
                
                    hypoxia
                 | 
            
                
                    
                        Fig. S5
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                whole organism nrp1a expression decreased amount, abnormal
             | 
                
                    WT + MO1-e2f7 + MO1-e2f8
                 | 
                
                    hypoxia
                 | 
            
                
                    
                        Fig. S5
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                trunk motor neuron nrp1a expression increased amount, abnormal
             | 
                
                    WT + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                motor neuron axon truncated, abnormal
             | 
                
                    js12Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                optic cup GFP expression increased amount, abnormal
             | 
                
                    js12Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 5  
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                motor neuron axon guidance decreased process quality, abnormal
             | 
                
                    js12Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                retina GFP expression increased amount, abnormal
             | 
                
                    js12Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 5  
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                angiogenic sprout physical object quality, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                intersegmental artery malformed, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1, 
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                angiogenesis process quality, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1, 
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                intersegmental artery branching involved in blood vessel morphogenesis decreased process quality, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1, 
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                dorsal longitudinal anastomotic vessel hypoplastic, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1, 
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                angiogenesis process quality, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8 + MO1-vegfaa
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                angiogenic sprout physical object quality, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8 + MO1-vegfaa
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                intersegmental artery branching involved in blood vessel morphogenesis decreased process quality, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8 + MO1-vegfaa
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                dorsal longitudinal anastomotic vessel hypoplastic, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8 + MO1-vegfaa
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                intersegmental artery malformed, abnormal
             | 
                
                    s843Tg + MO1-e2f7 + MO1-e2f8 + MO1-vegfaa
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                thoracic duct lymphangiogenesis disrupted, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                lymphangioblast cord lymphangioblast decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                intersegmental vein decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                thoracic duct morphology, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                intersegmental vessel decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                intersegmental vein angiogenic sprout decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                intersegmental artery decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                eye anatomical region hemorrhagic, abnormal
             | 
                
                    s843Tg; sd2Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                eye blood vessel malformed, abnormal
             | 
                
                    s843Tg; sd2Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                head hemorrhagic, abnormal
             | 
                
                    s843Tg; sd2Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                head blood vessel malformed, abnormal
             | 
                
                    s843Tg; sd2Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                intersegmental artery broken, abnormal
             | 
                
                    s843Tg; sd2Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 1
                    
                    from Weijts et al., 2012 
                
             | 
        
    
        
            | 
                lymphangiogenesis disrupted, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-ccbe1 + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                thoracic duct morphology, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-ccbe1 + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                lymphangioblast cord lymphangioblast decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-ccbe1 + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                dorsal longitudinal anastomotic vessel sprouting angiogenesis disrupted, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-ccbe1 + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                dorsal longitudinal anastomotic vessel separated from dorsal longitudinal anastomotic vessel, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-ccbe1 + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                intersegmental artery decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8 + MO4-dll4
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                lymphangioblast decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8 + MO4-dll4
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                intersegmental vessel increased branchiness, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8 + MO4-dll4
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                thoracic duct absent, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8 + MO4-dll4
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                sprouting angiogenesis disrupted, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8 + MO4-dll4
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                lymphangioblast cord lymphangioblast decreased amount, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8 + MO4-dll4
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                lymphangiogenesis disrupted, abnormal
             | 
                
                    hu5333Tg; y1Tg + MO1-e2f7 + MO1-e2f8 + MO4-dll4
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Weijts et al., 2013 
                
             | 
        
    
        
            | 
                motor neuron axon truncated, ameliorated
             | 
                
                    nrp1ahu10012/hu10012; js12Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6
                    
                    from de Bruin et al., 2016 
                
             | 
        
    
        
            | 
                motor neuron axon guidance decreased process quality, ameliorated
             | 
                
                    nrp1ahu10012/hu10012; js12Tg + MO1-e2f7 + MO1-e2f8
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6
                    
                    from de Bruin et al., 2016 
                
             |