PUBLICATION
Regulation of tooth development by the novel type I TGFbeta family member receptor Alk8
- Authors
- Payne, T.L., Skobe, Z., and Yelick, P.C.
- ID
- ZDB-PUB-020107-2
- Date
- 2001
- Source
- Journal of dental research 80(11): 1968-1973 (Journal)
- Registered Authors
- Payne-Ferreira, Tracie, Yelick, Pamela C.
- Keywords
- none
- MeSH Terms
-
- Bone Morphogenetic Proteins/genetics
- Bone Morphogenetic Proteins/physiology
- Tooth Germ/embryology*
- Molecular Sequence Data
- Amino Acid Sequence
- Zebrafish Proteins*
- Body Patterning
- Activin Receptors, Type I/biosynthesis
- Activin Receptors, Type I/genetics
- Activin Receptors, Type I/physiology*
- Signal Transduction
- Animals
- Odontogenesis/genetics*
- Mice
- Zebrafish/embryology
- Gene Expression Regulation, Developmental
- PubMed
- 11759004 Full text @ J. Dent. Res.
Citation
Payne, T.L., Skobe, Z., and Yelick, P.C. (2001) Regulation of tooth development by the novel type I TGFbeta family member receptor Alk8. Journal of dental research. 80(11):1968-1973.
Abstract
We have recently identified, in zebrafish, a novel type I receptor of the TGFbeta family, alk8, that participates in Bmp signaling pathways to mediate early dorsoventral patterning of neurectodermal and mesendodermal tissues. Since Bmps play significant roles in tooth specification, initiation, and differentiation, we hypothesized that alk8 may play a role in directing the Bmp-mediated epithelial mesenchymal cell interactions regulating tooth development. Immunohistochemical analysis demonstrates that Alk8 is expressed in developing zebrafish and mouse teeth. Examination of tooth development in zebrafish with disrupted alk8 signaling revealed specific defects in tooth development. Ectopic expression of constitutively active Alk8 results in the formation of elongated tooth structures, while expression of dominant-negative Alk8 results in arrested tooth development at the bud stage. These results are consistent with the established requirements for Bmp signaling in tooth development and demonstrate that Alk8 is a key regulator of tooth development
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping