PUBLICATION
Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function
- Authors
- Cornell, R.A. and Eisen, J.S.
- ID
- ZDB-PUB-020521-1
- Date
- 2002
- Source
- Development (Cambridge, England) 129(11): 2639-2648 (Journal)
- Registered Authors
- Cornell, Robert, Eisen, Judith S.
- Keywords
- neural crest; zebrafish; Delta/Notch signaling; Rohon-Beard neuron; bHLH; neurogenin; proneural genes; neurogenic genes
- MeSH Terms
-
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Zebrafish/physiology*
- Homeodomain Proteins/metabolism
- Neural Crest/physiology*
- Receptors, Notch
- Nerve Tissue Proteins/genetics*
- Trans-Activators/metabolism
- Gene Expression Regulation, Developmental
- Neurons, Afferent/cytology
- Membrane Proteins/metabolism*
- Transcription Factors/metabolism
- Zebrafish Proteins*
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/physiology
- Ganglia, Spinal/embryology
- Intracellular Signaling Peptides and Proteins
- PubMed
- 12015292 Full text @ Development
Citation
Cornell, R.A. and Eisen, J.S. (2002) Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function. Development (Cambridge, England). 129(11):2639-2648.
Abstract
In zebrafish, cells at the lateral edge of the neural plate become Rohon-Beard primary sensory neurons or neural crest. Delta/Notch signaling is required for neural crest formation. ngn1 is expressed in primary neurons; inhibiting Ngn1 activity prevents Rohon-Beard cell formation but not formation of other primary neurons. Reducing Ngn1 activity in embryos lacking Delta/Notch signaling restores neural crest formation, indicating Delta/Notch signaling inhibits neurogenesis without actively promoting neural crest. Ngn1 activity is also required for later development of dorsal root ganglion sensory neurons; however, Rohon-Beard neurons and dorsal root ganglion neurons are not necessarily derived from the same precursor cell. We propose that temporally distinct episodes of Ngn1 activity in the same precursor population specify these two different types of sensory neurons.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping