PUBLICATION
Using zebrafish to study the complex genetics of glaucoma
- Authors
- McMahon, C., Semina, E.V., and Link, B.A.
- ID
- ZDB-PUB-041111-11
- Date
- 2004
- Source
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 138(3): 343-350 (Review)
- Registered Authors
- Link, Brian, McMahon, Carrie
- Keywords
- Anterior segment; Complex disease; Eye; FoxC1; Glaucoma; Lmx1b; Pitx; Zebrafish
- MeSH Terms
-
- Glaucoma/genetics*
- Glaucoma/metabolism
- Glaucoma/pathology
- Zebrafish/genetics*
- Zebrafish/metabolism
- Animals
- Transcription Factors
- Homeodomain Proteins/genetics
- Homeodomain Proteins/metabolism
- Humans
- LIM-Homeodomain Proteins
- Fish Diseases/genetics
- Fish Diseases/metabolism
- PubMed
- 15533792 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Citation
McMahon, C., Semina, E.V., and Link, B.A. (2004) Using zebrafish to study the complex genetics of glaucoma. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):343-350.
Abstract
The overall goal of this review is to highlight the power of zebrafish as a model system for studying complex diseases which involve multiple genetic loci. We are interested in identifying and characterizing genes implicated in the blinding condition of glaucoma. Glaucoma is a complex disease that often involves multiple genetic loci. Most disease causing and modifying genes for glaucoma remain unidentified. However, several genes that regulate various aspects of ocular development have been shown to associate with glaucoma. With zebrafish, forward and reverse genetic approaches can be combined in order to identify critical genetic interactions required for normal and pathological events in the development and maintenance of the eye.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping