PUBLICATION
Assembly of trigeminal sensory Ganglia by chemokine signaling
- Authors
- Knaut, H., Blader, P., Strähle, U., and Schier, A.F.
- ID
- ZDB-PUB-050907-3
- Date
- 2005
- Source
- Neuron 47(5): 653-666 (Journal)
- Registered Authors
- Blader, Patrick, Knaut, Holger, Schier, Alexander, Strähle, Uwe
- Keywords
- none
- MeSH Terms
-
- Signal Transduction/physiology*
- Morpholines/pharmacology
- Animals
- Zebrafish
- Receptors, CXCR4/physiology
- Neurons, Afferent/physiology
- Ganglia, Sensory/cytology
- Ganglia, Sensory/physiology*
- Chemokines/physiology*
- Chemokines, CXC/biosynthesis
- Chemokines, CXC/genetics
- Chemokine CXCL12
- Cadherins/physiology
- Neurons/physiology
- Trigeminal Ganglion/cytology
- Trigeminal Ganglion/physiology*
- In Situ Hybridization
- PubMed
- 16129396 Full text @ Neuron
Citation
Knaut, H., Blader, P., Strähle, U., and Schier, A.F. (2005) Assembly of trigeminal sensory Ganglia by chemokine signaling. Neuron. 47(5):653-666.
Abstract
Sensory neurons with related functions form ganglia, but how these precisely positioned clusters are assembled has been unclear. Here, we use the zebrafish trigeminal sensory ganglion as a model to address this question. We find that some trigeminal sensory neurons are born at the position where the ganglion is assembled, whereas others are born at a distance and have to migrate against opposing morphogenetic movements to reach the site of ganglion assembly. Loss of Cxcr4b-mediated chemokine signaling results in the formation of mispositioned ganglia. Conversely, ectopic sources of the chemokine SDF1a can attract sensory neurons. Transplantation experiments reveal that neuron-neuron interaction and the adhesion molecules E- and N-Cadherin also contribute to ganglion assembly. These results indicate that ganglion formation depends on the interplay of birthplace, chemokine attraction, cell-cell interaction, and cadherin-mediated adhesion.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping