PUBLICATION
Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo
- Authors
- Hollway, G.E., Bryson-Richardson, R.J., Berger, S., Cole, N.J., Hall, T.E., and Currie, P.D.
- ID
- ZDB-PUB-070212-29
- Date
- 2007
- Source
- Developmental Cell 12(2): 207-219 (Journal)
- Registered Authors
- Berger, Silke, Bryson-Richardson, Robert, Cole, Nicholas, Currie, Peter D., Hall, Thomas
- Keywords
- none
- MeSH Terms
-
- Cell Lineage
- Body Patterning/physiology*
- Cell Compartmentation*
- PAX7 Transcription Factor/metabolism
- Stem Cells/cytology*
- Stem Cells/metabolism
- Somites/cytology
- Somites/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Embryo, Nonmammalian/cytology*
- Embryo, Nonmammalian/embryology
- Gene Expression Regulation, Developmental
- Muscle Cells/cytology*
- Muscle Cells/metabolism
- Zebrafish/embryology*
- Animals
- Rotation
- Signal Transduction
- PubMed
- 17276339 Full text @ Dev. Cell
Citation
Hollway, G.E., Bryson-Richardson, R.J., Berger, S., Cole, N.J., Hall, T.E., and Currie, P.D. (2007) Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo. Developmental Cell. 12(2):207-219.
Abstract
Somites are transient, mesodermally derived structures that give rise to a number of different cell types within the vertebrate embryo. To achieve this, somitic cells are partitioned into lineage-restricted domains, whose fates are determined by signals secreted from adjacent tissues. While the molecular nature of many of the inductive signals that trigger formation of different cell fates within the nascent somite has been identified, less is known about the processes that coordinate the formation of the subsomitic compartments from which these cells arise. Utilizing a combination of vital dye-staining and lineage-tracking techniques, we describe a previously uncharacterized, lineage-restricted compartment of the zebrafish somite that generates muscle progenitor cells for the growth of appendicular, hypaxial, and axial muscles during development. We also show that formation of this compartment occurs via whole-somite rotation, a process that requires the action of the Sdf family of secreted cytokines.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping