PUBLICATION
Somatosensory mechanisms in zebrafish lacking dorsal root ganglia
- Authors
- Honjo, Y., Payne, L., and Eisen, J.S.
- ID
- ZDB-PUB-110119-34
- Date
- 2011
- Source
- Journal of anatomy 218(3): 271-276 (Journal)
- Registered Authors
- Eisen, Judith S., Honjo, Yasuko
- Keywords
- DRG, erbb3, somatosensory, zebrafish
- MeSH Terms
-
- Animals, Genetically Modified/physiology
- Gene Expression Regulation
- Zebrafish/physiology*
- Receptor, ErbB-3/genetics
- Receptor, ErbB-3/physiology*
- Animals
- Immunohistochemistry
- Ganglia, Spinal/embryology
- Ganglia, Spinal/growth & development
- Ganglia, Spinal/physiology*
- PubMed
- 21235542 Full text @ J. Anat.
Citation
Honjo, Y., Payne, L., and Eisen, J.S. (2011) Somatosensory mechanisms in zebrafish lacking dorsal root ganglia. Journal of anatomy. 218(3):271-276.
Abstract
Dorsal root ganglion (DRG) sensory neurons transmit all somatosensory information from the trunk region of the body. erbb3 mutant zebrafish do not form DRG neurons because the neural crest cells that generate them migrate aberrantly. Here we report that homozygous erbb3 mutants appear to swim and feed normally, and that they survive through adulthood, despite never forming DRG neurons. The source of sensory compensation in adult erbb3 mutants remains unknown, although it may be from lateral line ganglion neuromasts which are reduced, but present, in erbb3 mutants. We also provide new information about the development of DRG neurons in wild-type juvenile zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping