PUBLICATION
Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems
- Authors
- Tay, T.L., Ronneberger, O., Ryu, S., Nitschke, R., and Driever, W.
- ID
- ZDB-PUB-110131-27
- Date
- 2011
- Source
- Nature communications 2: 171 (Journal)
- Registered Authors
- Driever, Wolfgang, Ryu, Soojin, Tay, Tuan Leng
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 21266970 Full text @ Nat. Commun.
Citation
Tay, T.L., Ronneberger, O., Ryu, S., Nitschke, R., and Driever, W. (2011) Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems. Nature communications. 2:171.
Abstract
Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extensive DA projections are established by posterior tubercular otp-dependent neurons, with individual somata integrating the ascending DA system, the descending diencephalospinal, as well as the endohypothalamic circuitry. These findings suggest a major role in the modulation of physiology and behaviour for otp-dependent DA neurons, which correlate with the mammalian A11 group. We further identified an endogenous subpallial DA system that not only provides most of the local DA projections, but also connects to the ventral diencephalon. The catecholaminergic projectome map provides a framework to understand the evolution and function of these neuromodulatory systems.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping